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Category Archives: Pharmaceuticals

Teratotoxicity in ZebraFish

Posted on 09-Jan-2016 by Mr. Mehul Pandya
Teratotoxicity in ZebraFish

Our team is excited about working with the zebra fish embryos for potential effects of the test chemicals. While working with the other tests, I came across articles, which indicated the application of this model for teratotoxicity as well! We note that the zebra fish organogenesis is perceptible within 3 to 5 days.  The models transparent embryos allow the observation of organ differentiation and development. We used Caffeine, Valproic acid and Retinoic acid... Continue Reading

Four crucial points to understand while designing your ADME program.

Posted on 27-Nov-2015 by Dr. Nadeem Khan
Four crucial points to understand while designing your ADME program.

DMPK has become a tool to optimize ADME properties in drug designing and screening. However, there are many related questions that often boggle the mind of a drug developer. Most importantly, there is a need to identify appropriate ADME tests required to conduct for preclinical studies. As a result, a few clarifications have become mandatory before initiating the ADME program 1. What should a representative IND package contain? Typical IND enabling package includes... Continue Reading