DUNS Number - 67-716-4521

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Chronic Toxicity

Chronic Toxicity

Mammalian toxicology assessments the short-term and extended exposure effects of the test compound on the biological functions.

The toxicology expertise at JRF encompasses a wide range of preclinical studies with rodents and non-rodents.  The studies are spread over a spectrum of specialties, viz., acute, sub-acute, sub-chronic, chronic, DART, in vitro and in vivo mutagenicity and Endocrine Disruptor Screening (Tier–1) using various routes of administration. These studies are performed in compliance with global regulatory guidelines, viz., OECD, OCSPP, EC, JMAFF, KCR (Indian requirements).
 

Repeat Dose Studies in Rodents and Non-Rodents

  • Sub-acute Toxicity 14 days DRF and 28 days (OECD 407)
  • Sub-chronic Toxicity (90 days) (OECD 408)
  • Subacute dog (OECD 409)
  • Subacute inhalation (OECD-412)
  • Chronic Toxicity (180  and 360 days)
  • Subchronic dog (OECD 409)
  • Carcinogenicity and Combined Carci (OECD 451, 452 and 453)


Developmental and Reproductive Toxicology

  • Reproduction/Developmental Toxicity Screening Test (OECD 421)
  • Acute neurotoxicity (OECD 424)
  • Combined Repeated Dose Toxicity Study with Reproduction / Developmental Toxicity Screening (OECD 422)
  • Prenatal Developmental toxicity (rats and rabbits; OECD 414)
  • Two generation Rrpotox (OECD 416)
  • Extended ine generation (OECD 443)
  • Developmental neurotox (OECD 426)


These studies can be offered to cover the cohorts to interpret the effects on the natural biological influences on Neurotoxicity

  • Immune syetems
  • Neural systems
  • Respiratory systems
  • Renal systems,
  • Hepatic processing
  • Peripheral systems including bone marrow
  • Circulatory systems (Toxicokinetics)
  • Specific biomarkers
  • Routine and specialized Hematology & Clinical chemistry
  • Hormonal assays
  • Conventional and targeted histopathology

Services available at following locations: