Our team is excited about working with the zebra fish embryos for potential effects of the test chemicals. While working with the other tests, I came across articles, which indicated the application of this model for teratotoxicity as well! We note that the zebra fish organogenesis is perceptible within 3 to 5 days.  The models transparent embryos allow the observation of organ differentiation and development. We used Caffeine, Valproic acid and Retinoic acid... Continue Reading

DMPK has become a tool to optimize ADME properties in drug designing and screening. However, there are many related questions that often boggle the mind of a drug developer. Most importantly, there is a need to identify appropriate ADME tests required to conduct for preclinical studies. As a result, a few clarifications have become mandatory before initiating the ADME program 1. What should a representative IND package contain? Typical IND enabling package includes... Continue Reading